Navigating Statistical Complexities in IV Iron and Hypertension Trials

This chapter explores the statistical implications of intravenous iron treatments on cardiovascular outcomes, focusing on the challenges presented by multiple outcome measures and the application of the Hochberg procedure. It discusses the nuanced interpretations of trial results, particularly for heart failure patients, while also examining the controversial timing of antihypertensive medication intake. Through this analysis, the chapter emphasizes the importance of robust statistical methods and careful clinical considerations in evaluating treatment efficacy.