All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/sapple

Sam Apple is the author of Ravenous: Otto Warburg, The Nazis, and the Search for the Cancer-Diet Connection.

Otto Warburg was a Nobel-Prize winning German scientist during the era of Hitler and the Nazi’s and he was the first person to put the metabolic story of cancer on the map. The famous “Warburg Effect” that shows how cancer cells have an increase in glucose uptake even in the presence of oxygen, is named after him.

It was a fascinating conversation talking about how the story of cancer research has evolved - how cancer cells eat to the discovery of oncogenes to coming full circle and making the connection between the two, and what the debate still holds in the story. We also talk about how cancer cells take up a lot of glucose, feed on sugar, and the connection between obesity and cancer. I hope you enjoy the conversation!

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SAM APPLE LINKS:

Ravenous book: https://amzn.to/3yT9qpd

Website: http://www.samapple.com/

Twitter: https://twitter.com/Sam_Apple1

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TIMESTAMPS:

0:00 Cancer as a disease of modern societies

1:27 Otto Warburg & the Cancer-Metabolic Connection

2:27 Warburg’s research on respiration

4:02 Why was cancer skyrocketing in Western societies?

9:17 Warburg Effect: Warburg’s research on cancer cells

15:00 Why do cancer cells take up so much glucose?

17:44 Cancer-Diet Connection

21:44 Cancer, Ketogenic diets & Fasting

23:43 Hibernation of the metabolic story of cancer

27:20 Hitler’s connection with cancer

30:07 Warburg’s arrogance

31:51 Why does cancer need glucose?

38:46 Warburg’s stigma: connecting with Nazi’s

40:51 Is insulin responsible for cancer?

48:00 Science is not immune from politics

50:24 Prostate cancer & obesity

52:13 Pendulum swing in cancer research

54:40 Mitochondria & Cancer Connection

57:07 Nazi’s fixation on cancer

Episode Show Notes: https://livelongerworld.substack.com/p/sapple

Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1

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Stay in good health - Aastha.

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