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Audio long read: Lab mice go wild — making experiments more natural in order to decode the brain

Nature Podcast

CHAPTER

The Role of Natural Behavior in Painkillers

A commonly used anti-inflammatory painkiller called Miloxacam seemed to work fine when tested in a standard pain assay. When the team observed mice behaving spontaneously, they noticed that certain actions, such as rearing onto the hind legs, persisted. This could explain why painkillers that seem to work in rodents have often failed in human trials. Other groups are also working on naturalistic models of pain.

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