Stress specifically CRH is one of the key things that induces mast cell activation. And so when CRH comes in over here, it activates the mast cell. The next thing that's kind of really interesting is that brain fog is also associated with a condition called POTS. So if you are laying down in bed and you jump upright out of bed, first of all, don't do this if you've got blood pressure problems because you could fall over.