2min chapter

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A controversial dam in the Amazon unites Indigenous people and scientists, and transplanting mitochondria to treat rare diseases

Science Magazine Podcast

CHAPTER

What Happens When You Have Major Deletion in Your Mitochondrial DNA?

This is a very complex question to answer. I don't think we can actually live with absence of parts of our mitochondria completely. And what we see in patients is that they have actually a state called heteroplasmy in which some of their mitochondria have normal mitochondrial DNA and some have deletions in the mitochondrial DNA. There's a lot of consequences to not having the full complement of mitochondria in working order.

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