The Genetics of Obesity

Click here to subscribe to Premium The pathogenesis of obesity is clearly complex. And the need to have a comprehensive model to explain this pathogenesis is important. One such model, termed the Energy Balance Model, has largely been the consensus paradigm of obesity scientists to this point. Specifically, a recently published paper in the American Journal of Clinical Nutrition by Dr. Kevin Hall and his colleagues outlined the various nuances of the model, as well as common misconceptions about the model. However, there are others who propose that this is not the correct model of obesity, but rather that obesity pathogenesis can be better explained by a model called the Carbohydrate-Insulin Model (CIM) of obesity. While this model has been proposed in various forms over the past couple of decades, the most recently published revision/update of this model was that put forward by Dr. David Ludwig and colleagues, in a Perspective published also in the AJCN, in December of 2021. In this episode, Dr. Kevin Hall (lead author of the paper mentioned above) and Dr. Stephan Guyenet are on the podcast to discuss the debate surrounding these two models. Specifically, the discussion will focus in on the Hall et al. (2022) and Ludwig et al. (2021) papers, as well as previous work leading up to both. Click here to access show notes for this episode

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