Is There a Link Between Chronic Kidney Disease and Diuretics?

There had been dogma from my training that you lost efficacy with the thiazide specifically as CKD progress though it sounds like maybe that thinking on that has evolved. And then there's also, I think as we mentioned earlier, you might just send someone crashing into end stage renal disease if you start up a loop diuretics. So how do you think about diuretics and patients that are at the stage and of their CKD? There are different treatments that probably partner with venkin beta which is slightly different Malaysianures but still sometimes if it's permanent, it does present their Wiki.