The Dipeptide Catalyst Is Not Heritable

The dipeptide that you used as a catalyst in this, at least in your system, is not heritable. That's why it's not true Darwinian evolution because it sells just happened to get lucky to have this catalyst but they don't make it themselves. And offspring doesn't make it either. Does this does this result answer or start to answer where we ought to be looking? I cannot say which one is better which one is more likely.

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What does it mean to be alive? Our origins are the horizon of our understanding, and as with the physical horizon, our approach brings us no closer. The more we learn, the more mysterious it all becomes. What if we’re asking the wrong questions? Maybe life did not begin at all, but rather coalesced piecemeal, a set of properties contingent and convergent, plural, more than once? Maybe the origin of life is happening right now, just over the horizon, forming something new anew. Let’s get into the weeds and see if we can find a continuity between biology and physics.

Welcome to COMPLEXITY, the official podcast of the Santa Fe Institute. I’m your host, Michael Garfield, and every other week we’ll bring you with us for far-ranging conversations with our worldwide network of rigorous researchers developing new frameworks to explain the deepest mysteries of the universe.

This week we speak with Kate Adamala, synthetic biologist and professor at the University of Minnesota, about her research to produce synthetic minimal cells that are not technically alive but can perform myriad biological processes. Along the way the distant past and future meet. Can we build life? Or can we grow machines?

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Podcast theme music by Mitch Mignano.

Referenced in this episode:

Nonenzymatic Template-Directed RNA Synthesis Inside Model Protocells

Engineering genetic circuit interactions within and between synthetic minimal cells

Competition between model protocells driven by an encapsulated catalyst

Synthetic cells in biomedical applications

Parasites, infections and inoculation in synthetic minimal cells

Build-a-Cell: Engineering a Synthetic Cell Community

The Andromeda Strain and the Meaning of Life: Monolith Monologues

Sara Walker on The Physics of Life and Planet-Scale Intelligence