This chapter critiques the Fermi paradox and its anthropocentric assumptions about extraterrestrial life, emphasizing the role of coevolution in our understanding of life on Earth and beyond. It delves into Earth's unique conditions for life emergence, including the transformative role of microorganisms, and examines how historical biological events relate to contemporary environmental challenges. The discussion extends to recent scientific advancements and the potential for future discoveries about alien life, integrating fields like quantum physics and astrobiology.