The Molecular Basis of the Most Omnipresent Energy

The molecule that was needed for the original prebiotic, prebiotic plausible membranes to coexist with the prebiotic genome of RNA is citric acid. "We have a plausible scenario that says that's how it could happen," he said. The work put together those three different essential parts of metabolism, the genome, the compartment, and herecitric acid.

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What does it mean to be alive? Our origins are the horizon of our understanding, and as with the physical horizon, our approach brings us no closer. The more we learn, the more mysterious it all becomes. What if we’re asking the wrong questions? Maybe life did not begin at all, but rather coalesced piecemeal, a set of properties contingent and convergent, plural, more than once? Maybe the origin of life is happening right now, just over the horizon, forming something new anew. Let’s get into the weeds and see if we can find a continuity between biology and physics.

Welcome to COMPLEXITY, the official podcast of the Santa Fe Institute. I’m your host, Michael Garfield, and every other week we’ll bring you with us for far-ranging conversations with our worldwide network of rigorous researchers developing new frameworks to explain the deepest mysteries of the universe.

This week we speak with Kate Adamala, synthetic biologist and professor at the University of Minnesota, about her research to produce synthetic minimal cells that are not technically alive but can perform myriad biological processes. Along the way the distant past and future meet. Can we build life? Or can we grow machines?

Be sure to check out our extensive show notes with links to all our references at complexity.simplecast.com. Note that applications are now open for our Complexity Postdoctoral Fellowships! If you value our research and communication efforts, please subscribe, rate and review us at Apple Podcasts or Spotify, and consider making a donation — or finding other ways to engage with us — at santafe.edu/engage.

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Podcast theme music by Mitch Mignano.

Referenced in this episode:

Nonenzymatic Template-Directed RNA Synthesis Inside Model Protocells

Engineering genetic circuit interactions within and between synthetic minimal cells

Competition between model protocells driven by an encapsulated catalyst

Synthetic cells in biomedical applications

Parasites, infections and inoculation in synthetic minimal cells

Build-a-Cell: Engineering a Synthetic Cell Community

The Andromeda Strain and the Meaning of Life: Monolith Monologues

Sara Walker on The Physics of Life and Planet-Scale Intelligence