congenital adrenal hyperplasia results in children that otherwise probably would have been assigned female at birth to either be born appearing so convincingly male. People who had been raised as girls start to aggressively essentially change their sex and become masculine, says Skylar O'Neill. In order to try and suppress the effects of the adrenal glands, he has to take a surgical procedure, she writes. "These are so dangerous that like patients die routinely"