Understanding Bone Marrow Failure Syndromes

Behold the field in which I grow my cells and see that it is barren. It’s out of the frying pan and into the aplastic fire with not a cell in sight. Join Nick, Cale and Bashar without two neutrophils to rub together as we talk about an approach to that most concerning of FBC features - pancytopenia. 

TIMESTAMPS

2:22 - Definition of pancytopenia  
4:23 - Spurious pancytopenia  
6:04 - Cutoffs (arbitrary as usual)  
9:43 - Acquired aplastic anaemia  
15:30 - Inherited bone marrow failure syndromes  
18:52 - Environmental toxins  
19:47 - Medications  
20:52 - Haematinic deficiencies  
25:59 - MDS/Leukaemias  
30:54 - Marrow suppression  
33:32 - Infiltrative causes  
36:45 - Viral causes  
38:05 - Approach to pancytopenia  
39:06 - History  
40:12 - Examination  
41:13 - Investigations  
42:27 - Liver failure  
44:30 - Take Home Messages  

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