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Stamping out high-risk myeloma with D-KRd and tandem transplant; plasmin-cleaved VWF in microthrombosis; SCD plasma sensitizes iPSC-derived sensory neurons

Blood Podcast

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Exploring Sensitization in Sickle Cell Disease Pain

The chapter delves into the heightened sensitization of sickle cell disease patient-derived sensory neurons to various stimuli, highlighting endothelin I signaling as a potential target. It emphasizes the importance of utilizing human-induced pluripotent stem cell-derived sensory neurons for studying novel pain targets in human tissue and advancing understanding of sickle cell pain mechanisms.

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