Episode 3.1: History of Acute Lymphoblastic Leukemia Treatment and Building the BFM Backbone
WolverHeme Happy Hour
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The History of CCG's BFM Backbone in High-Risk Ball Patients
The first study that CCG used to build upon the BFM, the German BFM backbone in high-risk patients was the CCG-1882 trial. The Germans showed that if you intensify their BFM backbone with high-dose air C or a top-aside or I-phosphamide, you're just going to get more toxicity and you're not going to get any more efficacy. And this is one of the reasons why pediatric-inspired regimens have so much asparigenase vincrystine and prednisone as opposed to more cytotoxic chemo.
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