C1 Inhibitor Deficiency Enhances Contact Pathway-Mediated Activity of Coagulation and Venous Thrombosis

C1 inhibitor deficiency enhances contact pathway-mediated activation of coagulation and venous thrombosis. Inherited mutations in the serp-ping-1 gene are the primary cause of hereditary angioedema, a rare disease characterized by recurrent, unpredictable, and potentially life-threatening episodes of swelling. Future studies should focus on more stringent and consistent molecular profiling of tumor samples to help personalize CAR T-cell therapy for individual patients.