RNA Based Sequencing Can Be Helpful for Fusion Detection

RNA in particular can be helpful for fusion detection just because commonly the break points of rearrangements are within the introns. It can also be more helpful for some other alterations like MET XM14 skipping. So in a patient where I have a high pre-test probability that they may have a driver I go through the algorithm that Ross mentioned which is what was the quality of this specimen? Was it a bone biopsy? What was the sequencing diversity?"