4min chapter

Sensible Medicine cover image

Sensible medicine

Sensible Medicine

CHAPTER

The Nonferiority Margin of Testosterone

The non-inferiority margin that they chose was 1.5, which means 1.5. That seems like if there's 50% more heart attacks in the testosterone arm, it would still be declared safe and cardiovascular safe. But when you look at their actual data, there's really no effect, right? The hazard ratio is close to one. And then what's amazing about this is in the less than three years that the trial went on, 60% of the men who were treated with testosterone stopped the medication. Why do they stop it? Do you know, wasn’t doing anything because they weren't really treated. It was the same level of stoppage as

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