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There's a little bit of an emotional component to allowing some of these close up sistems to make those decisions. We don't know if by being over sillous, in reducing the fi to exposure, we may cause more patients to go to the other side of the pendulum and the hypoemic. This has to be prospectively studied. There's certainly a are clinical trial in the u k, the ox p trial. And i think these ar the kind of studies that we need doing pat critical care to really determine what ranges we should be targeting.