4min chapter

Inside Exercise cover image

Glucose metabolism, exercise and the liver with Dr David Wasserman

Inside Exercise

CHAPTER

The Complexity of Cross-Linked Proteins

The liver is loaded with nerves, it's heavily innervated by the autonomic nervous system parasympathetic and sympathetic. And I think that this is a whole domain that remains to be fully defined. So there have been some terrific studies some of which by Matthew Watt, one of your homies in Melbourne. Some and others who've shown that you have proteins that are created by the liver and they can increase during exercise. Now what they do is the purpose of these four months, whether they're just whether they have a physiological role within the context of exercise remains to be better elucidated.

00:00
Speaker 2
And so, you know, you can start getting the heart is probably the same thing the heart as it starts to deteriorate you start getting heart failure you start getting liver failure, you know, if you start early enough, you can turn it around you can slow it down. But, you know, after a certain point
Speaker 1
you need a heart transplant you know, liver transplant, you know, right. Well, I think one of the, one of the problems, I think there, there are people who are have far more expertise and I do in this area but once you get to a certain point, you start developing all these cross linking proteins, and they have post translational modifications that extend their half life. And once a protein's cross linked it can be very hard to reverse that, and they can be around for years.
Speaker 2
All right, just to probably start thinking about wrapping up this has been great. One last thing I was thinking about was, you know, we're talking about all the complexity in the integration and things you start thinking about cross talk between organs so you know the we always think about the muscle talking to other structures such as I said I was six, being released for the muscle interacting with the liver. What's getting on the liver with cross talk is it's a liver communicating, you know, do you exercise with other organs is that other or needs talking to the liver. I know it's probably complex again
Speaker 1
but Well, it is. There's a lot of unknown untapped. There's been a lot to learn. So the liver is loaded with nerves, it's heavily innervated by the autonomic nervous system parasympathetic and sympathetic. That's a farrent and e farrent, but also there are proteins, and that are that are released from the liver. And I think that this is a whole domain that remains to be fully defined. In fact, I think maybe we've just scraped the surface. So there have been some terrific studies some, some of which by Matthew Watt, one of your homies in Melbourne. And some and others who've shown that you have proteins that are created by the liver and they can increase during exercise. Now what they do is the purpose of these four months, whether they're just whether they have a physiological role within the context of exercise remains to be better elucidated. What I tell people, and I'm asked this all the time. Just kidding, I'm rarely asked this. But the every organ, you can assume that there's communication with every between organs. The liver, the muscle, the liver, and it can be humeral or neural. And the blood. Yes, just a couple of people would be a bloodborne signal. And I think there's more that is unknown. But then is now right now, there's a lot to learn.
Speaker 2
Okay, great.

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