Optogenetic Therapy Partially Restores Vision

Can light restore aspects of sight? Can recalling a cold experience change an animal's metabolism? And what can ghost particles and mirror-image molecules tell us about the universe?

Lester Nare and Krishna Choudhary follow up on our 2026 Nobel Prize episodes with research building on optogenetics, IceCube and molecular handedness. We unpack an early human vision-restoration trial, cold-memory experiments in mice, cosmic neutrino flavors, and a tiny electrical sensor for distinguishing left- and right-handed amino acids.

Plus: how the Nobels work, our follow-up on the Nobel chemistry illustration, a brief look at neutrino Earth tomography, and why fundamental research matters. Which discovery would you like us to explore next?

CHAPTERS
00:00 Cold open: memory, neutrinos and mirror molecules
00:28 Hello Internet and how the Nobels work
04:32 Optogenetics recap
10:23 Restoring aspects of vision
25:43 Controlling movement in worms
29:31 Cold memories and metabolism
41:07 Memory, trauma and ethical questions
45:44 FFP housekeeping
48:17 IceCube recap
56:23 Measuring cosmic neutrino flavors
1:10:30 A brief look at neutrino Earth tomography
1:12:20 Why fundamental physics matters
1:26:58 Chemistry and molecular handedness
1:29:08 Correcting the Nobel illustration
1:39:30 Measuring chirality in tiny samples
1:46:42 Testing the sensor on meteorite and desert samples
1:51:22 Why these questions matter
1:57:20 Closing thoughts and signoff

RESEARCH & FURTHER READING
Optogenetic therapy for visual function (NEJM, 2026):
https://doi.org/10.1056/NEJMoa2602215

Cold memories and thermoregulation (Nature, 2025):
https://doi.org/10.1038/s41586-025-08902-6

Three-flavor composition of cosmic neutrinos (PRL, 2026):
https://doi.org/10.1103/vntd-m133

Chiral discrimination in meteorite and desert soil extracts (Nature Communications, 2026):
https://doi.org/10.1038/s41467-026-77947-6

Further reading, briefly mentioned: neutrino Earth tomography (preprint):
https://arxiv.org/abs/2607.02644

EDITORIAL NOTES
The vision trial was small and exploratory. The cold-memory findings discussed are from mice.

On-screen clarifications:
16:53 Both eyes were profoundly visually impaired; the worse-seeing eye was treated.
19:57 The untreated eye was patched during testing, not a normal-vision control.
54:41 Neutrino event rates depend on energy and selection, not just detector volume.
1:05:47 Flavor identification efficiency is distinct from interaction probability; both depend on energy.
1:13:35 Other astronomy-related Nobels include 2017 (LIGO) and 2019 (cosmology/exoplanets).
1:18:00 The LHC at CERN enabled the Higgs discovery; CERN itself was founded in 1954.
1:44:25 Both enantiomers produce current signals; waveform features distinguish them.
1:46:42 Murchison is a meteorite. Diego de Almagro and North of Antofagasta are soil sites.
1:47:40 The sensor study reports mixed agreement and limitations, not uniformly negative results.
1:49:00 Phobos is a Martian moon; a captured-asteroid origin is a hypothesis.

WATCH & LISTEN
Full video: https://youtu.be/C9K6onZxyN4
Episode notes: https://ffppod.com/episodes/ep64
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