Using Genome Sequencing Data to Improve Genotyping of Embryos

Shai Carmi is Professor of Statistical and Medical Genetics at Hebrew University (Jerusalem).

• Carmi Lab: https://scarmilab.org/
• Twitter: https://twitter.com/ShaiCarmi

 Topics and links:

1. Shai's educational background. From statistical physics and network theory to genomics.
2. Shai's paper on embryo selection: Schizophrenia risk. Modeling synthetic sibling genomes. Variance among sibs vs general population. RRR vs ARR, family history and elevated polygenic risk. (Link to paper: https://www.biorxiv.org/content/10.1101/2020.11.05.370478v3)
3. Response to the ESHG opinion piece on embryo selection. https://twitter.com/ShaiCarmi/status/1487694576458481664
4. Pleiotropy, Health Index scores.
5. Genetic genealogy and DNA forensics. Solving cold cases, Othram, etc. (Link to paper: https://www.science.org/doi/10.1126/science.aau4832)
6. Healthcare in Israel. Application of PRS in adult patients.

Music used with permission from Blade Runner Blues Livestream improvisation by State Azure.

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Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU.

Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on Twitter @hsu_steve.