TWiV 1239: Aluminum and antibodies
This Week in Virology
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Comparative Immune Responses to COVID-19 Vaccines
This chapter explores the differences in polyclonal antibodies generated from non-human primates and humans in response to the Moderna and Novavax COVID-19 vaccines. It discusses the immunogenic responses, antibody diversity, and efficacy against various SARS-CoV-2 variants, highlighting the structural distinctions between mRNA and protein-based vaccines. Advanced imaging techniques such as cryo-electron microscopy are utilized to reveal the complexities of antibody binding and the implications for vaccine design.
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