David Andrew Sinclair, PhD is an Australian biologist and professor of genetics. He is also a co-director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, and is known for his research on aging with a focus on epigenetics.
Time Stamps:
0:35:27 Podcast begins with David Sinclair
0:36:25 Is when we eat more important than what we eat?
0:38:45 What is the connection between time restrictive eating and longevity?
0:43:54 What causes us to age?
0:45:46 Epigenetic change.
0:52:03 What causes DNA breaks?
0:55:28 What plant foods create DNA breaks?
0:57:13 PARP enzymes
1:00:46 Where does NAD come from? How do we make it? What enzymes use it?
1:04:50 NAD recycling pathway.
1:12:13 Sirtuins.
1:24:14 What are the other longevity genes? (AMP kinase and mTOR) How are they connected to sirtuins?
1:31:50 Does being in a ketogenic state increase NAD?
1:40:30 Xenohormesis and plant molecules.
1:45:50 Resveratrol trials.
1:51:55 mTOR.
1:57:25 David’s thoughts on animal protein.
2:04:03 Meat consumption in relation to the environment and regenerative agriculture.
2:11:28 Where to find David Sinclair.
David’s info:
https://genetics.med.harvard.edu/sinc...
https://lifespanbook.com/
Instagram: @davidsinclairphd
Twitter: @davidasinclair
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