Testosterone and Immune Response Dynamics

This chapter explores the complex relationship between testosterone levels and the immune system, particularly focusing on how testosterone treatment affects immune cell populations. It discusses the suppression of immune responses related to type 1 interferon pathways and the role of key immune cells like plasmacytoid dendritic cells (PDCs) and natural killer (NK) cells. The chapter highlights findings from recent studies on gender-affirming therapy, emphasizing the need for further research to fully understand these intricate hormonal interactions.