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#470: Melatonin, Meal Timing & Glucose Tolerance

Sigma Nutrition Radio

CHAPTER

Melatonin Response in the Pancreas Is Impaired

It's a really strong first phase response but then we would expect it to come down quite sharply. But yeah I think this is important to contextualize that this and this may relate to melatonin right part of the mechanistic thinking. The hypothesis is that because of melatonin receptors in the pancreas if melatonin is elevated then you're basically getting an impaired ability of the pancrea to secrete insulin in response. So you're not getting the insulin response you need and as a result glucose is staying high.

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