The Role of PD1 and PDL1 in Regulating the Immune Response

This chapter explores the connection between TfH cells, checkpoint therapy, and the role of PD1 and PDL1 in regulating the immune response. It discusses the impact of blocking PD1 and PDL1 with therapeutic antibodies on terminal center cells near tumors, the correlation between tertium lymphoid structures and immunotherapies in human patients, and the successful treatment of different tumor types with PD1 or PDL1 blocking antibodies.