5min chapter

Raising Health cover image

Journal Club: Engineering Logic into CAR T Therapies with Robbie Majzner

Raising Health

CHAPTER

How to Identify Solid Tumor Cells as Cancerous

Two antigens or two proteins on the surface of disease cells must be present in order to get killing by a CAR T-cell. The problem with this approach is even first generation CARs, those that only contain CD3's ADAP, have caused this problem of on target off-tumor toxicity in the clinic. We haven't seen clinical data from this approach yet but we don't know if it might be okay.

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