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Ep. 50: “IUIS 2023: Where Immunologists Meet” Featuring Drs. Miriam Merad and Mark Davis

The Immunology Podcast

CHAPTER

The Effects of PD1 Signaling on Primary Tumors and Metastases

Tumor PD1 is also involved in other things, also within the T cells. I find it very interesting that it is in myeloid cells that are actually suffering more. It's not regardless of how big the primary tumor grows, this is what's engaging for the metastases. So they look at the tumor growth site versus metastasis and are finding out that knocking out the pathway doesn't necessarily have anything to do with the primary tumor but has to do with downstream metastasis control.

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