Refractory CMV, Resistance CMV?

The term resistant refractory disease is actually, I think a really nice one. It's something that we developed really kind of fleshed out in a working group called the CMV forum,. And it's interesting because it's people from academics, clinical medicine, diagnostic companies, therapeutic companies, the FDA, the European agencies. So everybody sort of comes to the table and agrees on the terminology. But when we do have resistance genes identified, I usually look up what the level of resistance is to gangcyclovir. Of course, you don't want to lose the organ or bone marrow transplant but reducing immunosuppression can be significantly helpful.