The Role of FOX-03 in 4-1 BB-Bearing CAR T-Sell Dysfunction

The discovery of a new molecular mechanism for 4-1 BB-bearing CAR T-Sells is remarkable. The transcription factor FOX-03 drove dysfunction in the 4-1BB-based CAR T- Sells. Trim II acts as a receptor for IL-34 to suppress acute myeloid leukemia in mice. It would be important to learn whether FOX-03 activation and the TBBD signature apply to patients with myeloma that relapse despite persistent BCMA directed CAR T-sells.