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15min chapter
Matt Kaeberlein on Rapamycin Longevity Series | Lessons learned from two decades of Rapamycin research
Master One Thing - Rapamycin Longevity Series
Exploring the Role of mTOR Signaling in Lifespan Extension
The chapter investigates the genetic screening process that identified the TOR gene and its connection to nutrient sensing and growth, leading to the discovery of rapamycin as an mTOR inhibitor that extends lifespan. It delves into the impact of variations in the mentor pathway on human longevity, considering mutations in mTOR and related disorders like tuberous sclerosis and dementia. The discussion highlights the interconnectedness of mTOR signaling with growth hormone and IGF-1 pathways, outlining how mutations in these pathways can influence longevity and explaining the mechanisms behind Rapamycin's lifespan extension abilities.
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