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What if the key to longevity isn’t found in your heart, your brain, or your hormones — but in your muscle?
In this episode of The Ready State Podcast, Dr. Gabrielle Lyon explains why skeletal muscle is the most overlooked organ in modern medicine and how its decline quietly drives aging, disease, and loss of independence. Drawing from her work in nutrition, geriatrics, and muscle-centric medicine, Lyon breaks down how strength training, protein intake, and daily movement protect metabolic health, resilience, and mental clarity as we age. From preventing sarcopenia to rethinking weight loss, GLP-1 drugs, and what it really means to age well, this conversation offers practical insights for anyone who wants to stay strong, capable, and useful for life. If you care about longevity, this episode reframes the conversation — starting with muscle!
WHAT YOU'LL LEARN IN THIS EPISODE
- Why cardiovascular disease, diabetes, obesity, and dementia often begin in skeletal muscle
- What “muscle-centric medicine” means — and why it challenges modern healthcare
- Why building muscle for longevity is the important thing you can do
- How GLP-1 drugs could unintentionally accelerate muscle loss and sabotage longevity
- Why body fat percentage misses the real metabolic problem
- How resistance training protects the brain, joints, and metabolism
- The protein framework Lyon uses in clinical practice
- Why movement is the fastest path to physical and mental freedom
TIMESTAMPS
(00:00) - Dr. Gabrielle Lyon
(01:20) - What Kind of Doctor Are You
(06:45) - Muscle-Centric Medicine Explained
(14:18) - Vitality Blueprint: $50 Off Plans
(16:45) - Role of a Muscle-Centric Physician
(19:15) - Muscle: The Organ of Longevity
(24:04) - Muscle Mass and Dementia Prevention
(27:10) - Fear of Resistance Training
(29:55) - Concerns About Being Too Bulky
(33:20) - LMNT
(35:00) - Subscribe to the Podcast
(32:50) - Importance of Healthy Muscle Mass
(40:00) - Best Ways to Measure Health Aging
(44:27) - Nutrition Insights
(50:07) - Staying Forever Young
(51:23) - Start Your Momentous Journey
(53:20) - The Forever Strong Playbook Overview
(54:15) - Understanding GLP-1s
(57:47) - Muscle-Centric Strength Program Overview
(59:35) - Expectations from The Forever Strong Playbook
(1:00:25) - Dr. Lyon’s addition to the Infinite Shelf
(1:01:11) - Finding Dr. Gabrielle Lyon
Huge thanks to our sponsors, Vitality, Momentous, and LMNT.
Connect with Dr. Lyon
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