The Effects of Genome Minimization on the Minimal Cell

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The initial effects of genome reduction were quite large. They made these cells sick. And when we measured the fitness of that organism at the end of the experiment, and we asked basically how sick is it now? We found that it recovered all of those fitness costs over the 2000 generations. So its fitness was equivalent to the original non minimize genome. But of course the non minimal cell evolved and became fitter during the 2000 generations as well.

In this episode:

00:46 The effects of evolution on a minimal genome

In 2016, researchers created a ‘minimal cell’ bacterium with a genome that only contains genes essential for the organism's survival. Any mutation in these genes could be fatal, so it was unclear whether there could be scope for evolution. But now, a team has grown this bacterium through 2,000 generations and shown that it does have the ability to evolve and can recover from some of the fitness costs associated with its streamlined genome.

Research article: Moger-Reischer et al.

09:21 Research Highlights

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Research Highlight: Dolphin mums whistle ‘baby talk’ with their calves

Research Highlight: What happens when you microwave that plastic bowl?

12:18 The first hints of giant gravitational waves

Gravitational waves were first detected in 2015, when two black holes collided — sending ripples in space-time across the Universe. Last week, four separate research collaborations found signatures of a wholly different kind of gravitational wave, with unknown origins. Nature’s Davide Castelvecchi explains how these waves were detected, and what this could mean for researchers’ understanding of black holes and the history of the cosmos.

Nature News: Monster gravitational waves spotted for first time

Nature News: Giant gravitational waves: why scientists are so excited

20:01 Briefing Chat

We discuss some highlights from the Nature Briefing. This time, new vaccine to protect Tasmanian devils against a deadly contagious cancer, and the ‘paradoxical’ palm that flowers and fruits underground.

Nature News: Tasmanian devil cancer vaccine approved for testing

The Guardian: ‘Mind-boggling’ palm that flowers and fruits underground thrills scientists

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