This chapter explores cardiovascular pharmacology, focusing on medications for arrhythmias, anti-anginal drugs, and vascular conditions. It highlights the physiology of cardiomyocytes and the significance of ionic movements in heart conduction, alongside a classification of anti-dysrhythmic drugs based on their actions on sodium channels. Additionally, the chapter delves into the therapeutic implications of class-specific medications in the management of heart conditions, including heart attacks and rhythm disorders.