Methylene Blue and Serotonin Syndrome

There are some clinical parameters where this is not something you should use. The major one would be G6PD deficiency, which is interestingly also a contraindication for high dose ascorbic acid treatments because that could be deadly. There is actually no evidence or oral methylene blue having interactions in this low dose range with any SSRI's. So yes, it is an effective to reduce symptoms of depression and unfortunately this warning is gonna make some decisions to be scared of using it in combination with SSRIs.