Ep 180 Acetaminophen Poisoning – Pitfalls in Assessment and Management
Emergency Medicine Cases
Is Hemodialysis a Standard of Care for Massive Acetaminophen Poison Patients?
The acetaminophen parent is responsible for at least some of the toxicity. We could clear it from the serum faster with dialysis. Fumepisol blocks the CIP-2E1 enzyme that metabolizes acetaminophen to NAP-key. There's evidence in animal studies, human volunteer studies that patients who are treated with hemepisol get a bit more benefit than just giving NAC.
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