Unlocking the Vagus Nerve

This chapter explores the importance of the vagus nerve and various techniques for its stimulation to enhance health, including lifestyle changes and clinical methods. It delves into the historical context of auricular therapy and its connection to the anatomical features and evolutionary biology of the vagus nerve. Additionally, the discussion covers the impact of vagus nerve stimulation on cognitive functions, psychiatric conditions, and the potential benefits of psychedelics and dietary choices in managing inflammation.

Transcript

chevron_right

Play full episode

chevron_right

Transcript

Episode notes

Kevin J. Tracey, MD is president and CEO of the Feinstein Institutes for Medical Research at Northwell Health, a pioneer of vagus nerve research and author of the recent book, The Great Nerve: The New Science of the Vagus Nerve and How to Harness Its Healing Reflexes.

This episode is brought to you by:

Eight Sleep Pod Cover 5 sleeping solution for dynamic cooling and heating: EightSleep.com/Tim (use code TIM to get $350 off your very own Pod 5 Ultra.)

AG1 all-in-one nutritional supplement: https://DrinkAG1.com/Tim (1-year supply of Vitamin D plus 5 free AG1 travel packs with your first subscription purchase.)

Wealthfront high-yield cash account: https://Wealthfront.com/Tim (Start earning 4.00% APY on your short-term cash until you’re ready to invest. And when new clients open an account today, you can get an extra fifty-dollar bonus with a deposit of five hundred dollars or more.) Terms apply. Tim Ferriss receives cash compensation from Wealthfront Brokerage, LLC for advertising and holds a non-controlling equity interest in the corporate parent of Wealthfront Brokerage. See full disclosures here.

Timestamps:

00:00 Tim’s intro: why he dismissed vagus-nerve hype

06:34 What the vagus nerve actually is, plus common myths

11:31 Breaking news: FDA approval for SetPoint’s RA implant + Kelly Owens’s turnaround

21:11 Inflammation 101: when healing turns harmful

31:37 Bioelectronic medicine: from lab insight to real devices

55:26 TNF, IL-1, and IL-6: immune drivers and what VNS modulates

56:06 Exercise & recovery: vagal signals, IL-6, and adaptation

56:30 Cold exposure & breathwork: sympathetic spike, parasympathetic payoff

59:04 Chronic inflammation today: prevalence, diagnostics, and uncertainty

59:53 Autoimmunity: genes, environment, infections

01:01:08 Stress hormones, personality traits, and metabolic fallout