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Managing and treating toxicities associated with CAR-T therapy: CRS, ICANS & infections

VJHemOnc Podcast

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Introduction

This chapter discusses strategies for minimizing cytokine release syndrome (CRS) and immune effect cell associated neurotoxicity syndrome (ICANS) in CAR T cell therapy, including the use of the Bedside EDG approach, close collaboration with neurologists and ICU doctors, and medications like anakinera and cetuximab. It also explores treatment approaches for severe and refractory CRS, such as tosyllismab, steroids, and emapalumab.

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