The Negative Effects of Salt Water on Kidney Function

The macula densa sees this increased chloride load and says, we're good on volume. We don't need any more. And then that induces renal afferent arteriolar vasoconstriction? Yes. This is called tubular glomerular feedback. It acts like a form of almost like auto regulation for the kidney so that it can control its own perfusion in response to volume loads. So given what you've told us about the potential negative effects of all this excess chloride, how is it that normal saline became the IV fluid du jour and maintain that as the top fluid for decades?"