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Ep150: Jeff Jonker on the Small Molecule Drug Discovery Renaissance

The Long Run with Luke Timmerman

CHAPTER

Covalent and non-covalent binding in small molecule drug discovery

This chapter explores the concept of covalent binding and its effectiveness in cancer treatment. It discusses the advantages of covalent binding in targeting cancer cells without severe side effects, and highlights the potential of non-covalent binding for chronically administered diseases. The chapter also discusses the innovative approach of a company that uses non-covalent chemical attachment and UV light activation for effective screening and characterization.

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