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Is Double Labeled Water a Valid Method for Looking at Total Daily Energy Expense?
Doubly labelled water is a different approach to estimating energy expenditure. It works by enriching the participants body water with heavy isotopes of oxygen and hydrogen. By looking at those wash out kinetics, usually measured based on urine sampling, you get a really good idea of the overall rate of carbon dioxide production. And you can use that to then estimate total daily energy expenditure in people who are just going about day to day lives.