Innovations in CAR-T Therapy for Solid Tumors

This chapter explores the advancements in CAR-T cell therapy aimed at solid tumors, particularly focusing on BCMA as a key antigen. It discusses the challenges presented by hostile tumor microenvironments and innovative strategies to enhance CAR-T cell effectiveness and persistence. Moreover, the chapter addresses the dual-therapeutic approach with a virus targeting epithelial-origin cancers, highlighting preliminary data that indicates a promising future in combating various cancers.