Adrenocortical carcinoma (ACC) is a rare and aggressive cancer that forms in the outer layer of the adrenal gland tissue above the kidneys. According to the National Institutes of Health, the occurrence of ACC in the United States is believed to only affect one to two people per million, per year. This highly-rare disease also challenges patients and researchers due to its post-diagnosis five-year survival rate of a mere 51%.
At this time, there are no known external factors that cause this disease. Most adrenocortical tumors that have been found produce symptoms including abdominal pain and higher levels of certain hormones, inclusive of cortisol, aldosterone, testosterone, and estrogen. Any of these hormones produced in excess can have numerous troubling effects on the body and, most alarmingly, the cancer cells in the adrenal glands have the potential to travel to other organs.
Researchers—from the National Cancer Institute, Stanford University, Medical College of Wisconsin, Frederick National Laboratory for Cancer Research, and Salubris Biotherapeutics—conducted a study to learn more about ACC and the mechanisms that lead to the biological materialization of this ultra-rare disease. In 2020, their research paper was published by Oncotarget and entitled, “GATA3 and APOBEC3B are prognostic markers in adrenocortical carcinoma and APOBEC3B is directly transcriptionally regulated by GATA3.”
Full blog - https://www.oncotarget.org/2022/01/26/study-demonstrates-excess-of-protein-is-regulated-by-gata3-in-ultra-rare-adrenal-cancer/
DOI - https://doi.org/10.18632/oncotarget.27703
Correspondence to - Electron Kebebew - kebebew@stanford.edu
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Press release - https://www.oncotarget.com/news/pr/gata3-and-apobec3b-are-prognostic-markers-in-adrenocortical-carcinoma-and-apobec3b-is-directly-transcriptionally-regulated-by-gata3/
Keywords - adrenocortical carcinoma, APOBEC3B, GATA3, prognosis, DNA damage
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