Speaker 2
there's, there's a tremendous amount of work in this area over the last decade, plas us. And i think you know that th the beneficial effects of of it are are not not huge. You can point to many, many pipes which have a lot of big climes associated with them. A and but in times of the animal models, which is where probably the best quality diter is, the benefits are not, they're not dramatic. Theyre, they're, they're, they're good, you know, theyre, they're t a lot of these things i worry about from the perspective of am genetic diversity and am sedentary animal models. You're fixing something which is broke, but you're not really improving something. It's a little bit like, in mind oou cloric restriction shouldn't really be called chloric restriction. It should be called cloric optimization. It's, it's, what you're doing is you're just going back to whatt you were referring to earlier, normal levels of food. When you over eat, bad things happen. That happens a lot in mouse colonies, i tell you, mal mice frequently will be like 50 grams. Now, a normal young mouse is about 30 grams, 25, 30 grams. But as they get older, they're just that in all o can eat buffa all day, all long. And the many of the males get up tob 50 grams. Now, that's abeast mouse. And we know that when you're a beast, bad things happen, and that that shortens your life. And the same thing we know for many studies in human beings, thata, youow, optimizing your your caloriesa is beneficial to your health in the long run and maximizes your longevity. And and say, i think a lot of the studies which, which show marginal effects, like ten %, 15 % improvement in x y o, whatever. Ah, they might be fixing something which is broke inn in the mouse, because it's an inbred model. Ah, you know, it's, it's eating all the time. It's not got a lot of exercise, a. And so, you know, maybe we should rel think how to do those animal studies. Oh, i would love to be able to omise the mice so that they were kind of like elete athletes with a pristine diet. And, you know, some of, some of the mice, most mice live to about, you know, two years, maybe three if they're lucky. But there are some species of mice which live eight years. So that's a big different ybut those are not the mice which are commonly studied. So, so it makes you wonder aways studying short lived strains of mice and then fixing things which are brokin them, and then proclaiming a big bikshire. I don't know, but it worries me.
Speaker 1
I've, i've said something similar on this show for years now, the science sciences should be studying athletes, athletic types, those of ar because because you study sick people, you don't find out why they're sick. If you study, if you study letic people, people who train, rest, eat appropriately, and, you know, they live the life of an athlete. You don't have to be a pro athlete. You can be an average slug like me. But look at us. We're aging better. Why don't you want to know why we're aging better? Sciencists don't want to know that.