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Do Wild Mice Have Long Telomeres?
Mice with long telomeres are prone to tumors and resistant to damage. This means they make terrible models for drug safety because you can give them a toxic insult. The mice that we get all come from a tiny number of sources in the US it's largely the Jack's lab in Bar Harbor, Maine. These mice have been distorted by their evolutionary environment in this way that makes them terrifically prone to cancer and terrificallyresistant to damage. If you use those mice in a drug safety test what you will typically get is a clean bill of health. Now I find myself whistleblower twice over in the same story decades apart.