Did Life and Microbiome Evolve with Gravity?

Gravity may be the most ignored signal in human biology, and it could be the missing key to unlocking fat loss, brain optimization, and true longevity. In this episode, you’ll learn how Earth’s pull shapes your metabolism, mood, and resilience, and discover practical hacks to fight “gravity intolerance” so you can perform better, live longer, and upgrade every system in your body. 

Watch this episode on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Dr. Brennan Spiegel, a Professor of Medicine and Public Health at UCLA, Director of Health Services Research at Cedars-Sinai, and author of Pull: How Gravity Shapes Your Body, Steadies the Mind, and Guides Our Health. A leading voice in digital health and immersive medicine, Dr. Spiegel brings decades of clinical and research experience exploring the intersection of the gut-brain axis, neuropsychology, and mind-body medicine. In this episode, he reveals why gravity influences everything from gut health to depression — and why modern medicine has largely ignored its role. His work bridges functional medicine, neuroscience, and biohacking to uncover a hidden force that shapes human performance at every level. 

You’ll Learn: 

• Why gravity is the most ignored biohacking signal in human health 

• How gravity intolerance shows up as back pain, fatigue, obesity, and depression 

• The surprising connection between gravity, serotonin, and mood regulation 

• How weighted vests, balance boards, and proprioception training hack graviception 

• Why sleep optimization, posture, and fascia resilience are gravity-based health tools 

• How Earth’s pull influences gut health, metabolism, and even consciousness 

You’ll learn how gravity connects to obesity, back pain, blood pressure, serotonin, and even consciousness. Dave and Dr. Spiegel explore how weighted vests, balance boards, vibration, and sleep optimization can hack your body’s response to gravity.  

This channel dives into mitochondria, neuroplasticity, fasting, ketosis, supplements, and how biohackers can apply these insights alongside tools like cold therapy, nootropics, and even Danger Coffee to build resilience and extend longevity. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 

New episodes are released every Tuesday, Thursday, Friday (audio-only), and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: Gravity intolerance, Graviception, Serotonin and gravity, Tensegrity fascia system, Interstitium organ discovery, Piezoelectric cell membranes, Weighted vest training health, Balance board proprioception, Inclined bed sleep therapy, Gravity and depression, Obesity as a gravity disease, Low blood pressure gravity link, Crohn’s disease altitude flares, Gravity and microbiome diversity, Glymphatic drainage sleep optimization, Space travel gravity health risks, Astronaut vision loss microgravity, Vagus nerve and gravity, Collagen and gravity resilience, Barefoot running gravity mechanics 

Thank you to our sponsors!  

• Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. 
• Timeline | Head to https://www.timeline.com/dave to get 20% off. 

Resources:  

• Pre-order Brennan’s Book: https://a.co/d/ik2C9iB 

• Danger Coffee: https://dangercoffee.com/discount/dave15 

• Dave Asprey’s BEYOND Conference: https://beyondconference.com 

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated 

• Upgrade Collective: https://www.ourupgradecollective.com 

• Upgrade Labs: https://upgradelabs.com 

• 40 Years of Zen: https://40yearsofzen.com 

Timestamps: 

0:00 — Trailer 

1:30 — Intro 

4:14 — Gravity and Human Evolution 

5:39 — Why Medicine Ignores Gravity 

8:43 — Signs of Gravity Intolerance 

12:18 — Training Gravity Resilience 

16:46 — Gravity in Space 

20:34 — Managing Gravity When Flying 

23:59 — NASA’s Gravity-Diet Link 

26:55 — Serotonin and Gravity 

37:42 — Gravity and Sleep 

50:24 — Obesity as a Gravity Issue 

55:39 — Movement and Balance 

57:38 — Gravity-Resistant Exercises 

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