The Health Risks of Hormonal Therapy

Most of the safety data regarding hormone therapy comes from the Women's Health Initiative trial that I mentioned. Neither conjugated equine estrogen alone nor the combination with metroxi progesterone acetate significantly increases the risk of coronary heart disease, Dr. Crandall says. Transdermal preparations probably confer less risk of venosomal embolism, especially in younger recently post-menopausal women, he adds.