Biological information storage and DNA computing

In this episode of the Crazy Wisdom podcast, host Stewart Alsop talks with Umair Siddiqui about a wide range of interconnected topics spanning plasma physics, aerospace engineering, fusion research, and the philosophy of building complex systems, drawing on Umair’s path from hands-on plasma experiments and nonlinear physics to founding and scaling RF plasma thrusters for small satellites at Phase Four; along the way they discuss how plasmas behave at material boundaries, why theory often breaks in real-world systems, how autonomous spacecraft propulsion actually works, what space radiation does to electronics and biology, the practical limits and promise of AI in scientific discovery, and why starting with simple, analog approaches before adding automation is critical in both research and manufacturing, grounding big ideas in concrete engineering experience. You can find Umair on Linkedin.

Check out this GPT we trained on the conversation

Timestamps

00:00 Opening context and plasma rockets, early interests in space, cars, airplanes
05:00 Academic path into space plasmas, mechanical engineering, and hands-on experiments
10:00 Grad school focus on plasma physics, RF helicon sources, and nonlinear theory limits
15:00 Bridging fusion research and space propulsion, Department of Energy funding context
20:00 Spin-out to Phase Four, building CubeSat RF plasma thrusters and real hardware
25:00 Autonomous propulsion systems, embedded controllers, and spacecraft fault handling
30:00 Radiation in space, single-event upsets, redundancy vs rad-hard electronics
35:00 Analog-first philosophy, mechanical thinking, and resisting premature automation
40:00 AI in science, low vs high hanging fruit, automation of experiments and insight
45:00 Manufacturing philosophy, incremental scaling, lessons from Elon Musk and production
50:00 Science vs engineering, concentration of effort, power, and progress in discovery

Key Insights

1. One of the central insights of the episode is that plasma physics sits at the intersection of many domains—fusion energy, space environments, and spacecraft propulsion—and progress often comes from working directly at those boundaries. Umair Siddiqui emphasizes that studying how plasmas interact with materials and magnetic fields revealed where theory breaks down, not because the math is sloppy, but because plasmas are deeply nonlinear systems where small changes can produce outsized effects.
2. The conversation highlights how hands-on experimentation is essential to real understanding. Building RF plasma sources, diagnostics, and thrusters forced constant confrontation with reality, showing that models are only approximations. This experimental grounding allowed insights from fusion research to transfer unexpectedly into practical aerospace applications like CubeSat propulsion, bridging fields that rarely talk to each other.
3. A key takeaway is the difference between science and engineering as intent, not method. Science aims to understand, while engineering aims to make something work, but in practice they blur. Developing space hardware required scientific discovery along the way, demonstrating that companies can and often must do real science to achieve ambitious engineering goals.
4. Umair articulates a strong philosophy of analog-first thinking, arguing that keeping systems simple and mechanical for as long as possible preserves clarity. Premature digitization or automation can obscure understanding, consume mental bandwidth, and even lock in errors before the system is well understood.
5. The episode offers a grounded view of automation and AI in science, framing it in terms of low- versus high-hanging fruit. AI excels at exploring large parameter spaces and finding optima, but humans are still needed to judge physical plausibility, interpret results, and set meaningful directions.
6. Space engineering reveals harsh realities about radiation, cosmic rays, and electronics, where a single particle can flip a bit or destroy a transistor. This drives design trade-offs between radiation-hardened components and redundant systems, reinforcing how environment fundamentally shapes engineering decisions.
7. Finally, the discussion suggests that scientific and technological progress accelerates with concentrated focus and resources. Whether through governments, institutions, or individuals, periods of rapid advancement tend to follow moments where attention, capital, and intent are sharply aligned rather than diffusely spread.