GDF-15 on its own isn't enough to increase energy expenditure above baseline levels. But what we will do is it will prevent the slowdown in metabolism that occurs with dieting or caloric restriction. And this is quite important in the context of we now have a series of drugs that suppress feeding, and these drugs have been very successful in our causing weight loss. So using GDF-15 it may be more effective when used with either a dieting regime or with a caloric suppressing agent because it will keep that energy burning.

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