Immune 48: Environmental enteric dysfunction with Timothy Hand
Immune
Getting Deep in the Weeds
In the lymph node, we shockingly didn't see a difference in CCR9 and alpha-4 beta-7 expression. So it seemed like the cells were being primed correctly. Here the dendritic cells were trafficking just fine. And so what we hypothesized at that point was there's something local about the small intestine that was preventing the cells from functioning once they got there. We tested that pretty carefully. And it looked like the T cells were getting the right, you know, address signals so they could end up in the intestine.
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